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09/11/2023
Statistical and Practical Considerations in Planning and Conduct of Dose Optimization Trials
The US Food and Drug Administration launched Project Optimus with the ai...
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05/20/2023
SAM: Self-adapting Mixture Prior to Dynamically Borrow Information from Historical Data in Clinical Trials
Mixture priors provide an intuitive way to incorporate historical data w...
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02/19/2023
Design and Sample Size Determination for Multiple-dose Randomized Phase II Trials for Dose Optimization
The conventional more-is-better dose selection paradigm, which targets t...
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11/03/2022
Seamless Phase 2-3 Design: A Useful Strategy to Reduce the Sample Size for Dose Optimization
The traditional more-is-better dose selection paradigm, developed based ...
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10/24/2022
SpacePhish: The Evasion-space of Adversarial Attacks against Phishing Website Detectors using Machine Learning
Existing literature on adversarial Machine Learning (ML) focuses either ...
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09/04/2022
DROID: Dose-ranging Approach to Optimizing Dose in Oncology Drug Development
In the era of targeted therapy, there has been increasing concern about ...
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12/31/2021
Bayesian Nonparametric Common Atoms Regression for Generating Synthetic Controls in Clinical Trials
The availability of electronic health records (EHR) has opened opportuni...
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12/20/2021
BOP2-DC: Bayesian optimal phase II designs with dual-criterion decision making
The conventional phase II trial design paradigm is to make the go/no-go ...
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12/04/2020
Optimal Bayesian hierarchical model to accelerate the development of tissue-agnostic drugs and basket trials
Tissue-agnostic trials enroll patients based on their genetic biomarkers...
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09/13/2020
Elastic Priors to Dynamically Borrow Information from Historical Data in Clinical Trials
Use of historical data and real-world evidence holds great potential to ...
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06/10/2020
A novel sentence embedding based topic detection method for micro-blog
Topic detection is a challenging task, especially without knowing the ex...
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04/27/2020
Incorporating historical information to improve phase I clinical trial designs
Incorporating historical data or real-world evidence has a great potenti...
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10/12/2018
Bayesian Hierarchical Spatial Model for Small Area Estimation with Non-ignorable Nonresponses and Its Applications to the NHANES Dental Caries Assessments
In order to identify the demographic or dental hygienic factors that rel...
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10/08/2018
Social Network Mediation Analysis: a Latent Space Approach
Social networks contain data on both actor attributes and social connect...
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10/01/2018
TOP: Time-to-Event Bayesian Optimal Phase II Trial Design for Cancer Immunotherapy
Immunotherapies have revolutionized cancer treatment. Unlike chemotherap...
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07/23/2018
Time-to-Event Model-Assisted Designs to Accelerate Phase I Clinical Trials
Two useful strategies to speed up drug development are to increase the p...
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12/18/2017
